NOW FOODS SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW® SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.* Product Uses: Natural Antidepressant The most compelling clinical evidence for SAMe is the hundred-plus published studies regarding its benefit in depression. SAMe is the most well-documented non-drug antidepressant available today. SAMe has been proven effective in every type of depression, and seems particularly good for the endogenous form, where people are depressed without any apparent external cause. Bipolar depression (manic depressive) may be an exception to SAMe's otherwise good record. SAMe can cause some people with this type of depression to switch from depression to mania. This effect does not always occur. SAMe's anti-depressant effect begins anywhere from immediately to 5 weeks. Most patients benefit within 4 days, which is faster than most antidepressant drugs. Depression Caused by Organic Disease SAMe has been tested for depression caused by a variety of diseases, including Parkinson's Disease (PD), fibromyalgia, cancer, cardiovascular disease, and rheumatoid arthritis. And researchers have used SAMe successfully in conjunction with drug and alcohol withdrawal. Fibromyalgia Fibromyalgia is a recently recognized disorder which is regarded as a common cause of chronic musculoskeletal pain and fatigue. Fibromyalgia shares many common features with another recently termed syndrome, the chronic fatigue syndrome (CFS). The only difference in diagnostic criteria for fibromyalgia and CFS is the requirement of musculoskeletal pain in fibromyalgia and fatigue in CFS. The likelihood of being diagnosed as having fibromyalgia or CFS depends on the type of physician consulted. Specifically, if the patient consults a rheumatologist or orthopedic specialist, he or she is much more likely to be diagnosed with fibromyalgia than CFSs. Depression is often an underlying finding in both fibromyalgia and CFS. Three clinical studies show SAM produces excellent benefits in patients suffering from fibromyalgia. One such study was a double-blind, crossover study of 17 patients with fibromyalgia. During treatment with SAM (200 milligrams daily by injection for 21 days), subjects demonstrated significant reduction in the number of trigger points and painful areas and improvements in mood. Migraine SAM is beneficial in the treatment of migraine headaches. The benefits manifest gradually and require long-term treatment for therapeutic effectiveness. Dosage Ranges In general, the longer SAM is used, the more beneficial the results. It is perfectly suited for long-term use because of its excellent safety profile. Here are the dosage ranges for the various clinical indications. Depression- Four hundred milligrams three to four times daily. Because SAM can cause nausea and gastrointestinal disturbances in some people, it should be started at a dosage of 200 milligrams twice daily for the first day, increased to 400 milligrams twice daily on day three, 400 milligrams three times daily on day ten, and finally to the full dosage of 400 milligrams four times daily after 20 days if needed. Fibromyalgia- Two hundred milligrams to 400 milligrams two times daily. Details: Enteric Coated SAMe is a supplement formed in the body by an enzymatic reaction between adenosine-triphosphate (ATP) and methionine. It was discovered in 1952 in Italy and has been researched and manufactured there. SAMe works closely with folic acid and vitamin B-12,and functions as a methyl donor. This nutrient carries and donates methyl molecules necessary to facilitate the manufacture of DNA and brain neurotransmitters. Tissue levels of SAMe are typically low in the elderly. Suggested Use: As a dietary supplement, take 1 tablet, 2 to 4 times daily, preferably on an empty stomach. Refrigeration recommended after opening. Warnings: Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision. Please discard the inedible freshness packet enclosed. Free Of: yeast, corn, soy, wheat, milk, gluten. Other Ingredients: Cellulose, Mannitol, Hydroxypropyl Methylcellulose Phthalate, Citric Acid, Sodium Starch Glycolate, Glyceryl Triacetate, Croscarmellose Sodium, Stearic Acid and Silica Potency: 200 MG S u p p l e m e n t F a c t s: Serving Size: 1 Tablet Servings Per Container: 30 SAMe (S-Adenosyl-L-Methionine) 100 mg* (from 200 mg of S-Adenosyl-L-Methionine Disulfate Tosylate) ** These statements are not intended to diagnose or treat any disease. |
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